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Posted by Sunny
on 11/2/2009, 1:12 pm, in reply to "actually.."
24.113.27.183 | Message modified by user Sunny 11/2/2009, 1:15 pm
are not the same. Yes, Cushings absolutely increases drinking and urination, but IR on it's own does not neccesarily do the same thing (and yes, they often happen together, but not always). The reason glucose does not spill into the urine in the horse is it never really gets that high in a horse. The glucose threshold for the kidneys is pretty high and since horses do not get severe hyperglycemia, they don't get glucose in the urine. The reason you do the glucose insulin ratio to detect IR, is that the glucose alone is usually not that high, so not diagnostic.
IR is more similar to type II diabetes as you said, however there are still huge differences. It's really more like what they call metabolic syndrome in people.
I'm not surprised pergolide decreased the urination, that suggests it was caused by the Cushings though, as pergolide does not treat IR
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